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ID: 66214
Title: High Sensitivity Electrochemical Detector for U(HPLC) Decade ELITE
Author: -(Spotlight)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 97-97 August (2023)
Subject: High Sensitivity Electrochemical Detector for U(HPLC) Decade ELITE
Keywords: None
Abstract: The DECADE Elite electrochemical detector from Antee Scientific works with any HPLC and UHPLC system and is by far the most sensitive electrochemical detector by today's standards. With a 'high frequency' data rate, it can handle the fast-eluting peaks in UHPLC. It is further compatible with capillary and nano-LC a well, when coupled with Antec's proprietary small volume SenCell. In the DECADE Elite, the column and the flow cell are both held at a very accurate and stable temperature up to 60 Deg C. Specially developed low-pass Advanced Digital Filter (ADF) suppresses noise originating from HPLC and electrochemical flow cell, passing only signals with a frequency lower than a selected cut-off frequency (chrmomatographic peaks) and attenuating higher frequencies (i.e., noise reduction).By selecting the appropriate filter settings signal to noise (S/N) ratio can be improved substantially, up to 100 fold.
Location: T E 15 New Biology building
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ID: 66213
Title: Vacuum Hydrogen Peroxide (DLVHP/DE Series Passbox fr Decontamination
Author: -(Spot light)
Editor: None
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 96-96 August (2023)
Subject: Vacuum Hydrogen Peroxide (DLVHP/DE Series Passbox for Decontamination
Keywords: None
Abstract: De Lauma hydrogen peroxide decontamination pass-box sets now standards of performance and repeatability for surface decontamination of loads and in particular offers completely new advantages. Hydrogen Peroxide has chemical-physical characteristics that give very good compatibility with many materials such as electronics, aluminum, stainless steel, glass, polyethylene, polypropylene, PTFE.
Location: T E 15 New Biology building
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ID: 66212
Title: Low-temperature Evaporative Light Scattering Detector for HPLC SEDEX 85LT
Author: -(Spot light)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 94-94 August (2023)
Subject: Low-temperature Evaporative Light Scattering Detector for HPLC SEDEX 85LT
Keywords: None
Abstract: SEDEX Model 85 LT Low-Temperature Evaporative Light Scattering Detector for HPLC offers excellent sensitivity, reliability and accuracy, thanks to the unrivalled SEDERE low-temperature technology. As an example, the SEDEX with a flow rate of 1 mL/min at 32 Deg C. Detection is based on a universal property of all analytes and does not require the presence of any chromophoric group, electroactive group, etc. As the response is directly related to the mass of the eluted compound the detector provides similar response factors for molecules
Location: T E 15 New Biology building
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ID: 66211
Title: Universal separation System for Macromolecules AF2000 Multiflow FFF
Author: -(Spot light)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 90-93 August (2023)
Subject: Universal separation System for Macromolecules AF2000 Multiflow FFF
Keywords: None
Abstract: Asymmetric Flow Field-Flow Fractionation (AF4) is an innovative new method for the efficient separation and characterization of proteins, polymers and nanoparticles in a fast and gentle way that prevents shearing, degradation and interactions that are typical of column-based separations. Detection of very high molar mass aggregates and large species which otherwise will not elute from SEC columns, is no more a challenge, thanks to the unique separation capabilities of the Postnova's revolutionary FFF systems.AF4 can be readily interfaced with other characterization techniques such as Multi Angle Light Scattering (MALS) for characterization of absolute molar mass and root-mean-square radious (radious of gyration) of analytes. Nanoparticles can be separated from 1 nano meter to 100 mume meter &proteins, peptides, polymers from 10E3 to 10E 12 Da. The fast and gentle separation occurs based on the diffusion coefficient of the analytes in an open flow channel without using ANY stationary phase.
Location: T E 15 New Biology building
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ID: 66210
Title: UHPLC with IoT & AI enhancemnets N-series The Next Gen UHPLC
Author: -(Analytical Intelligence)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 84-88 August (2023)
Subject: UHPLC with IoT & AI enhancemnets N-series The Next Gen UHPLC
Keywords: None
Abstract: Shimadzu N-series HHPLC system cutting edge Artificial Intelligence and Internet of Things (IoT) enhancemnts to achieve improved operational efficiency and reliable LC analysis. The N-series can be set to start up at a specified time, so that it can complete auto-purge, equilibration and baseline checks in advance and be ready for analysis before the analyst enters the lab. Reservoir try weight sensors measure the real time volume of mobile phase in the bottle and alerts are sent to users if quantities go down below pre-set levels. Flow pilot (Smart Flow Control) system can be used to increase the flow rate gradually to the set point in conjunction with the column temperature which increases the lifetime of column an protects it from high pressure due to sudden pump starts/stops or extreme gradient changes.
Location: T E 15 New Biology building
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ID: 66209
Title: Subvisible Particle Analysis using Background Membrane Imaging (BMI) Technology (USP<788>)
Author: -(Application brief)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 78-82 August (2023)
Subject: Subvisible Particle Analysis using Background Membrane Imaging (BMI) Technology (USP<788>)
Keywords: None
Abstract: Subvisible particulate matter present in biopharmaceutical injections and parenteral infusions has been strongly linked with immunogenecity. USP<788> is the compendial chapter referenced by the FDA that establishes biopharmaceutical lot release guidelines and limits for subvisible particles. The two methods described in USP <788> are light obsecuration (USP<788> Method 1) and membrane microscopy due to its lack of automation along with its error prone and arduous manual analysis .However, the USP<788> chapter and its informational chapter <1788> recommends membrane microscopy over light obsecutration when handling complex, high viscosity and low-volume samples, which is where a large part of biopharmaceutical development is now focused.
Location: T E 15 New Biology building
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ID: 66208
Title: High-parameter phenotypic and functional characterization of Cancer-Immune Cells
Author: -(Application brief)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 72-75 August (2023)
Subject: High-parameter phenotypic and functional characterization of Cancer-Immune Cells
Keywords: None
Abstract: Interrogating immune cell composition and function in patients with cancer is critical for making disease prognoses, monitoring clinical efficacy of tumor immunotherapies, identifying novel therapeutic targets, and discovering predictive biomarkers of disease. Both the adaptive and innate arms of the immune system play important roles in generating pro-or anti-tumor milieus. Effector cells such as NK cells and T cells can directly kill tumor cells via secretion or cell-surface expression of cytolytic proteins and modulate the immune response through costimulatory molecules.
Location: T E 15 New Biology building
Literature cited 1: Witzing,T.E. et al.Detection of myeloma cells in the peripheral blood by flow cytometry 26 (1996).113-120. Kumar, S. et al.'I immunophenotyping in multiple myeloma and related plasma cell disorders'. Best Practice & Research Clinical Hematology 23 (2010).433-451
Literature cited 2: Ahn,E. et al. 'Role of PD-1 during effector CD8 T cell differentiation' Proceedings of the National Academy of Sciences of the United States of America 115 (2018).4, 749-4,754. Benson, D.M. et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody' Blood 116 (2010): 2,286-2,294.

ID: 66207
Title: Accurate cell counting of peripheral Blood Mononuclear Cells (PBMCs) in blood with contaminated RBCs
Author: -(Application Brief)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 56-58 August (2023)
Subject: Accurate cell counting of peripheral Blood Mononuclear Cells (PBMCs) in blood with contaminated RBCs
Keywords: None
Abstract: Accurate cell counting of peripheral blood mononuclear cells (PBMCs) is essential in a range of research applications. However, obtaining reliable PBMC counts can be tricky. Even if you carefully isolate your PBMCs, some red blood cell contamination can remain.
Location: T E 15 New Biology building
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ID: 66206
Title: Analysis of Anionic polar pesticides without derivatization in Mango
Author: -(Application brief)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 64-67 August (2023)
Subject: Analysis of Anionic polar pesticides without derivatization in Mango
Keywords: None
Abstract: The use of pesticides in the environment is constantly under review, as pesticide residues on crops meant for consumption and feed production can pose health risks. Hence, regulations are put in place to regulate the use of pesticides and monitor the maximum residue levels allowable in food and crop produce. The use of hazard-based approach in food safety regulation has led to an increased use of polar pesticides, which exhibit lower persistence and toxicity.
Location: T E 15 New Biology building
Literature cited 1: Commission Regulation (EU)No. 293/2013 o 20 March 2013 https://eur-lex.europa.eu/eli/reg/2013/293/oj (Accessed on 8 July 2022) Commission Regulation (EU)2017/1777 of 29 September 2017 https://eur-lex-europa.eu/lega content.EN/uri=CELEX%3A32017R1777 (Accessed on 8 July 2022)
Literature cited 2: M.Kawashima.Shimadzu Appl.News C181 (2018) M.Kawashima.Shimadzu Appl.News C210A (2021)

ID: 66205
Title: Preparative Purification of Ibuprofen and Related Substances
Author: -(Application brief)
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 60-62 August (2023)
Subject: Preparative Purification of Ibuprofen and Related Substances
Keywords: None
Abstract: Preparation and purification by liquid chromatography is a widely used technique in the pharmaceutical, food and chemical industries for drug synthesis, finding effective compounds in natural products, and for structural analysis of unknown trace compounds, Nexera UFPLC enables substantial labor savings in preparative purification by automating not only the fractionation of the target compound but also related processes such as concentration, purification and recovery. This article describes an example of preparative purification of a mixed sample of the pharmaceutical ibuprofen and its analogues using Nexera UFPLC.
Location: T E 15 New Biology building
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ID: 66204
Title: Rapid quantification o fVitamin D2 and D3 in Dietary supplements
Author: Dr. Devasena Kannan and Dr. Sagar Utture
Editor: C.Ravindranath, D.Uma Raghuram, Saptarshi Chaudhari, T.Parthasarthy, Amirtha Vasudevann, Arvind Thyagarajan
Year: 2023
Publisher: Spinco Biotech Cutting Edge
Source: ENVIS, CES & EWRG, CES
Reference: Spinco Biotech Cutting Edge Vol. 13 (4) 56-58 August (2023)
Subject: Rapid quantification o fVitamin D2 and D3 in Dietary supplements
Keywords: None
Abstract: Vitamin D is a group of fat-soluble compounds of which Vitamin D2 (Ergocalciferol) and Vitamin D3 (Cholecalciferol)are the two main forms. According to the British Pharmcopeia, several methods have been developed for the analysis of Vitamin D, but the sensitivity and selectivity that HPLC can achieve make it the best technique of choice for routine various reasons including the fact the at they are clinically phosphate in the body.The differentiation between D2 and D3 is critically important as the concentration levels of both the compounds must the preciously measured to understand their individual and combined effects in the body.
Location: T E 15 New Biology building
Literature cited 1: Shimadzu Application Data on High-speed Analysis of Vitamin D.http://shimadzu.com.du/sites/default/files/HPLC_VitD_datasheet_19_en.pdf. Zane Temova and Robert Roskar (2016). Stability -indicating HPLC-UV Method for Vitamin D-3 Determination in Solutions, Nutritional Supplements and Pharmaceuticals, Journal of Chromatographic Sciences, 54 (7), 1180-1186.
Literature cited 2: Sarioglu et al (2001). A rapid method for determination of Vitamins D2 and D3 in pharmaceutical preparations by HPLC. Journal of Liquid Chromatography and Related Technologies, 24 (7), 973-982.

ID: 66203
Title: Why woodpeckers don’t get concussions
Author: Sam Van Wassenbergh; Maja Mielke
Editor: Richard J.Fitzgerald
Year: 2024
Publisher: American Institute of Physics
Source: ENVIS, CES & EWRG, CES
Reference: Physics Today Vol. 77 (1) 32 -38, January (2024)
Subject: Why woodpeckers don’t get concussions
Keywords: None
Abstract: When knocking away pieces of hard woody bark to find food, digging nesting holes into tree stems, or making drumming sounds to lure mates or announce their territories, woodpeckers generally strike trees with their beaks at speeds of 20 kilometers per hour and can reach rates up to 30 times per second during drumming. So a sudden deceleration would exceed the threshold that would render a concussive blow— at least to a human brain. But to judge from many popular accounts, internet blogs, information panels in zoos, and educational television programs, the birds’ brains emerge unharmed thanks to shock- absorption structures in the skull.
Location: T E 15 New Biology building
Literature cited 1: S. Van Wassenbergh et al., “Woodpeckers minimize cranial absorption of shocks,” Curr. Biol. 32, 3189 (2022). A. A. Biewener, “Physiology: Woodpecker skulls are not shock absorbers,” Curr. Biol. 32, R767 (2022)
Literature cited 2: L. J. Gibson, “Woodpecker pecking: How woodpeckers avoid brain injury,” J. Zool. 270, 462 (2006). E. R. Schuppe et al., “Evolutionary and biomechanical basis of drumming behavior in woodpeckers,” Front. Ecol. Evol. 9, 649146 (2021).

ID: 66202
Title: The new laser weapons
Author: Thomas Karr and James Trebes
Editor: Richard J.Fitzgerald
Year: 2024
Publisher: American Institute of Physics
Source: ENVIS, CES & EWRG, CES
Reference: Physics Today Vol. 77 (1) 32 -38, January (2024)
Subject: The new laser weapons
Keywords: None
Abstract: DEWs recently existed only in science fiction, commonly seen in the Star Wars movies and in the Star Trek television series. Despite the excitement among developers and many billions of dollars in military funding over six decades, lasers and other directed-energy devices were not common operational weapons. Indeed, developers of traditional kinetic-energy weapons (KEWs)—guns, bombs, and missiles, for instance— have jokingly said that DEWs are “the weapons of tomorrow, and always will be.” But because of recent technical advances and changes in military conditions, they are currently getting a serious reappraisal by military planners, and the US and several other nations are putting them in the field. The technical advances have led to compact solid-state HELs that are scalable to high power, and the changes in military conditions include an exponential increase in offensive threats that cannot be fully addressed by defensive KEWs alone. Today the US military fields 21 laser weapons whose average power varies from a few watts to 60 kW, and the Department of Defense’s High Energy Laser Scaling Initiative (HELSI) has demonstrated three lasers with an average power of 300 kW in three distinct laser architectures.
Location: T E 15 New Biology building
Literature cited 1: N. Bloembergen et al., Rev. Mod. Phys. 59, S1 (1987). M. D. Perry et al., “Laser containing a distributed gain medium,” US Patent 6,937,629 B2 (30 August 2005).
Literature cited 2: W. F. Krupke, Prog. Quantum Electron. 36, 4 (2012). J. Detsch, “The U.S. Army goes to school on Nagorno-Karabakh conflict,” Foreign Policy, 30 March 2021; A. Hickey, “Houthi drone strikes on energy infrastructure: A 6-month outlook,” Grey Dynamics, 13 December 202

ID: 66201
Title: Developing trustworthy AI for weather and climate
Author: Amy McGovern, Philippe Tissot, and Ann Bostrom
Editor: Richard J.Fitzgerald
Year: 2024
Publisher: American Institute of Physics
Source: ENVIS, CES & EWRG, CES
Reference: Physics Today Vol. 77 (1) 26 -31, January (2024)
Subject: Developing trustworthy AI for weather and climate
Keywords: None
Abstract: Imagine that high-impact weather phenomena, such as those described above, are forecast with sufficiently advanced warning and precision that humankind is able to significantly mitigate the effects of such events globally. Furthermore, the predictions are known to be trustworthy, so individuals and local and state governments can act immediately to save lives and property. Such a scenario is not just a vision: It may be a reality in a few years. As the climate changes, weather extremes are affecting species and ecosystems around the globe—and are becoming more extreme (see the article by Michael Wehner, Physics Today, September 2023, page 40). At the same time, recent developments in artificial intelligence (AI) and machine learning (ML) are showing how that vision might be realized.
Location: T E 15 New Biology building
Literature cited 1: S. Russell, P. Norvig, Artificial Intelligence: A Modern Approach, 4th ed., Pearson (2021). A. McGovern et al., Bull. Am. Meteorol. Soc. 98, 2073 (2017); S. E. Haupt et al., Bull. Am. Meteorol. Soc. 103, E1351 (2022).
Literature cited 2: H. R. Glahn, D. A. Lowry, J. Appl. Meteorol. Climatol. 11, 1203 (1972). I. Goodfellow, Y. Bengio, A. Courville, Deep Learning, MIT Press (2016).

ID: 66200
Title: Teaching physics with phones: A game changer?
Author: David Kramer
Editor: Richard J.Fitzgerald
Year: 2024
Publisher: American Institute of Physics
Source: ENVIS, CES & EWRG, CES
Reference: Physics Today Vol. 77 (1) 23 -25, January (2024)
Subject: Teaching physics with phones: A game changer?
Keywords: None
Abstract: Virtually every high school and college student in high-income countries has at their fingertips a powerful and versatile tool, equipped with all the sensors and visualizations needed to do experiments suitable for an introductory physics course. But most physics educators have yet to catch on to the opportunities that could arise from using smartphones in their labs. “By far the greatest number of teachers in high school and college are still completely unaware of the potential of these devices,” says David Rakestraw, who has spent the past four years at Lawrence Livermore National Laboratory developing hundreds of physics experiments for smartphones and a 3000-page guide to performing them. “It’s difficult to get people to recognize new ideas and implement them, particularly because the vast majority of teachers don’t know where to find information,” he says.
Location: T E 15 New Biology building
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